He also does weight lifting once or twice a week. One reason is that there are more and better studies done with fisetin showing longevity effects, such as studies in mice demonstrating that fisetin extends lifespan (R). I do a mix of running and HIIT. Fasting activates sirtuins, exercise activates sirtuinsthe generic things that doctors tell us to do, we believe are mediated through sirtuins, explains Sinclair. Like many people, his diet varies and he likes to experiment with different ones. 10 Best Anti-Cancer Supplements for Cancer Prevent Alzheimer's Disease 101: Can Alzheimers Disease B Krill Oil vs Fish Oil vs Cod Liver Oil: What's the 12 Best Stem Cell Supplements to Naturally Boost S Peter McCullough: Nattokinase in the Prevention an NAC vs NAD vs NR vs NMN? In fact, if you dont take high-dose iodine supplements or dont eat seaweed regularly, its very likely you are deficient [], NR (nicotinamide riboside) and NMN (nicotinamide mononucleotide) supplements are both often touted as two of the most promising supplements to slow down aging. When the growth pathway is active, and the body is getting lots of calories, cellular growth machinery like mTOR The 'mammalian Target Of Rapamycin.' NR is, in fact, converted into NMN. Despite all the hype on the internet, NR does not extend lifespan (R). Calories Insights and interesting reads delivered straight to your inbox. David These genes are working in concert with one another.. So what supplements does Dr. Sinclair take to live longer? Its the same idea as the old aphorism that which doesnt kill you, makes you stronger.. Furthermore, David Sinclair takes metformin in the evening, before going to bed. Eat less meat, eat more plants. We often see that people who look considerably younger for their age have the following things in common: Professor David Sinclair is a shining example of these important longevity lifestyle factors. Theres a lot of evidence that caloric restriction works and exercise works., RELATED READING: Dr. Andrew Hubermans Sleep Cocktail, Dr. David Sinclair believes that exercise should be high-intensity so it can trigger The Epigenetic clock.